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Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Although γ-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding this therapeutic strategy. However, it is not known whether moderate inhibition of this enzyme will allo...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Neurosci
Main Authors: Li, Tong, Wen, Hongjin, Brayton, Cory, Laird, Fiona M., Ma, Guojun, Peng, Shiwen, Placanica, Lisa, Wu, T. C., Crain, Barbara J., Price, Donald L., Eberhart, Charles G., Wong, Philip C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Society for Neuroscience 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672827/
https://ncbi.nlm.nih.gov/pubmed/17913918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2152-07.2007
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