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Proteasome-mediated effects on amyloid precursor protein processing at the γ-secretase site
Aβ (β-amyloid) peptides are found aggregated in the cortical amyloid plaques associated with Alzheimer's disease neuropathology. Inhibition of the proteasome alters the amount of Aβ produced from APP (amyloid precursor protein) by various cell lines in vitro. Proteasome activity is altered duri...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134727/ https://ncbi.nlm.nih.gov/pubmed/15473868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041145 |
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