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Proteasome-mediated effects on amyloid precursor protein processing at the γ-secretase site

Aβ (β-amyloid) peptides are found aggregated in the cortical amyloid plaques associated with Alzheimer's disease neuropathology. Inhibition of the proteasome alters the amount of Aβ produced from APP (amyloid precursor protein) by various cell lines in vitro. Proteasome activity is altered duri...

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Bibliografske podrobnosti
Main Authors: Flood, Fiona, Murphy, Suzanne, Cowburn, Richard F., Lannfelt, Lars, Walker, Brian, Johnston, Janet A.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134727/
https://ncbi.nlm.nih.gov/pubmed/15473868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041145
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