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Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct

γ-Secretase activity is associated with a presenilin (PS)-containing macromolecular complex. Whether PS contains the active site of γ-secretase has been controversial. One challenge is to find PS that is engaged in the active γ-secretase complex at the cell surface, where some substrates appear to b...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Tarassishin, Leonid, Yin, Ye Ingrid, Bassit, Bhramdeo, Li, Yue-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535399/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15563588/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408007101
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