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Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct
γ-Secretase activity is associated with a presenilin (PS)-containing macromolecular complex. Whether PS contains the active site of γ-secretase has been controversial. One challenge is to find PS that is engaged in the active γ-secretase complex at the cell surface, where some substrates appear to b...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15563588/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408007101 |
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