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In Vivo Manifestation of Notch Related Phenotypes in Zebrafish Treated with Alzheimer’s Amyloid Reducing γ-Secretase Inhibitors
γ-Secretase is responsible for the final cleavage of amyloid precursor protein to generate the amyloid-β protein, the major component of plaques in the brains of Alzheimer’s disease patients. γ-Secretase inhibitors (GSI) have been explored for therapeutic inhibition of Aβ generation, but mechanistic...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539131/ https://ncbi.nlm.nih.gov/pubmed/20345767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06681.x |
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