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A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
Inhibition of amyloid β-peptide (Aβ) production by blocking γ-secretase activity is at present one of the most promising therapeutic strategies to slow progression of Alzheimer’s disease pathology. γ-secretase inhibitors apparently block Aβ generation via interference with presenilin (PS) function....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084181/ https://ncbi.nlm.nih.gov/pubmed/12101103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf124 |
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