Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology

γ-Secretase processing of the amyloid precursor protein (APP) generates Aβ(40) and Aβ(42), peptides that constitute the principal components of the β-amyloid plaque pathology of Alzheimer's disease (AD). The γ-secretase activity is executed by a high-molecular-weight complex of which presenilin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Deng, Yu, Tarassishin, Leonid, Kallhoff, Verena, Peethumnongsin, Erica, Wu, Ling, Li, Yue-Ming, Zheng, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674120/
https://ncbi.nlm.nih.gov/pubmed/16597739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5384-05.2006
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge