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Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology
γ-Secretase processing of the amyloid precursor protein (APP) generates Aβ(40) and Aβ(42), peptides that constitute the principal components of the β-amyloid plaque pathology of Alzheimer's disease (AD). The γ-secretase activity is executed by a high-molecular-weight complex of which presenilin...
Kaydedildi:
| Yayımlandı: | J Neurosci |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Society for Neuroscience
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6674120/ https://ncbi.nlm.nih.gov/pubmed/16597739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5384-05.2006 |
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