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Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production

Processing of the amyloid precursor protein (APP) by β- and γ-secretases generates pathogenic β-amyloid (Aβ) peptides associated with Alzheimer disease (AD), whereas cleavage of APP by α-secretases precludes Aβ formation. Little is known about the role of α-secretase cleavage in γ-secretase regulati...

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Detalhes bibliográficos
Main Authors: Tian, Yuan, Crump, Christina J., Li, Yue-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952257/
https://ncbi.nlm.nih.gov/pubmed/20675367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128439
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