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Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production
Processing of the amyloid precursor protein (APP) by β- and γ-secretases generates pathogenic β-amyloid (Aβ) peptides associated with Alzheimer disease (AD), whereas cleavage of APP by α-secretases precludes Aβ formation. Little is known about the role of α-secretase cleavage in γ-secretase regulati...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952257/ https://ncbi.nlm.nih.gov/pubmed/20675367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128439 |
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