Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Although γ-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding this therapeutic strategy. However, it is not known whether moderate inhibition of this enzyme will allo...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Li, Tong, Wen, Hongjin, Brayton, Cory, Laird, Fiona M., Ma, Guojun, Peng, Shiwen, Placanica, Lisa, Wu, T. C., Crain, Barbara J., Price, Donald L., Eberhart, Charles G., Wong, Philip C.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2007
Предметы:
Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672827/
https://ncbi.nlm.nih.gov/pubmed/17913918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2152-07.2007
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы