Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Although γ-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding this therapeutic strategy. However, it is not known whether moderate inhibition of this enzyme will allo...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Li, Tong, Wen, Hongjin, Brayton, Cory, Laird, Fiona M., Ma, Guojun, Peng, Shiwen, Placanica, Lisa, Wu, T. C., Crain, Barbara J., Price, Donald L., Eberhart, Charles G., Wong, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672827/
https://ncbi.nlm.nih.gov/pubmed/17913918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2152-07.2007
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