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Transcription-mediated replication hindrance: a major driver of genome instability

Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enha...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Gómez-González, Belén, Aguilera, Andrés
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672053/
https://ncbi.nlm.nih.gov/pubmed/31123061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.324517.119
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