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The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this instability is mediated by cotranscriptional R loops, which are believed to increase by suboptimal assembly of the nascent messenger ribonucleoprotein particle (mRNP). However, no...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3841734/ https://ncbi.nlm.nih.gov/pubmed/24240235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.229880.113 |
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