The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability

Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this instability is mediated by cotranscriptional R loops, which are believed to increase by suboptimal assembly of the nascent messenger ribonucleoprotein particle (mRNP). However, no...

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Autores principales: Santos-Pereira, José M., Herrero, Ana B., García-Rubio, María L., Marín, Antonio, Moreno, Sergio, Aguilera, Andrés
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841734/
https://ncbi.nlm.nih.gov/pubmed/24240235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.229880.113
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