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Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a differential implication of mRNP biogenesis factors in genome integrity in yeast and humans. We show that human THO depletion impairs transcription elongation...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228816/ https://ncbi.nlm.nih.gov/pubmed/22144908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002386 |
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