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Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitation (ChIP)-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-de...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160181/ https://ncbi.nlm.nih.gov/pubmed/21701562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.206 |
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