Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitation (ChIP)-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-de...

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Hlavní autoři: Gómez-González, Belén, García-Rubio, María, Bermejo, Rodrigo, Gaillard, Hélène, Shirahige, Katsuhiko, Marín, Antonio, Foiani, Marco, Aguilera, Andrés
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160181/
https://ncbi.nlm.nih.gov/pubmed/21701562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.206
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