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Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch recombination. AID acts on ssDNA, and switch regions of Ig genes, a target of AID, form R-loops that contain ssDNA. Nevertheless, how AID action is specifically targeted to particul...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895963/ https://ncbi.nlm.nih.gov/pubmed/17488823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702836104 |
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