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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Altered amyloid precursor protein (APP) processing leading to increased production and oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP processing is regulated under physiological conditions may provide new insights into AD pathogenesis. Recent reports dem...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Hoey, Sarah E., Williams, Robert J., Perkinton, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665739/
https://ncbi.nlm.nih.gov/pubmed/19357271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6017-08.2009
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