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Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies

Amyloid-β peptide (AβP) that accumulates in the Alzheimer's diseased brain is derived from proteolytic processing of the amyloid precursor protein (APP) by means of β- and γ-secretases. The β-secretase APP cleaving enzyme (BACE), which generates the N terminus of AβP, has become a target of int...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Arbel, Michal, Yacoby, Iftach, Solomon, Beka
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2005
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140443/
https://ncbi.nlm.nih.gov/pubmed/15894613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502427102
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