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Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies

Amyloid-β peptide (AβP) that accumulates in the Alzheimer's diseased brain is derived from proteolytic processing of the amyloid precursor protein (APP) by means of β- and γ-secretases. The β-secretase APP cleaving enzyme (BACE), which generates the N terminus of AβP, has become a target of int...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Arbel, Michal, Yacoby, Iftach, Solomon, Beka
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140443/
https://ncbi.nlm.nih.gov/pubmed/15894613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502427102
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