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An antibody to the β-secretase cleavage site on amyloid β-protein precursor inhibits amyloid β production

Proteolytic cleavage of amyloid β-protein precursor (AβPP) by β– and γ–secretases results in production of the amyloid β peptide (Aβ) that accumulates in the brains of sufferers of Alzheimer’s Disease (AD). We have developed a monoclonal antibody, 2B12, which binds in the vicinity of the β-secretase...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Alzheimers Dis
Päätekijät: Thomas, Rhian S., Liddell, J. Eryl, Murphy, Lynne S., Pache, David M., Kidd, Emma J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492742/
https://ncbi.nlm.nih.gov/pubmed/17183149
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