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Anti-amyloid precursor protein antibodies inhibit amyloid-β production by steric hindrance
Cleavage of amyloid precursor protein (APP) by β- and γ-secretases results in the production of amyloid-β (Aβ) in Alzheimer’s disease (AD). We raised two monoclonal antibodies, 2B3 and 2B12, that recognise the β-secretase cleavage site on APP but not Aβ. We hypothesised that these antibodies would r...
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| Publicado no: | FEBS J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492582/ https://ncbi.nlm.nih.gov/pubmed/21122073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2010.07942.x |
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