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The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human α(V)β(3) Integrin via Steric Hindrance
The LM609 antibody specifically recognizes α(V)β(3) integrin and inhibits angiogenesis, bone resorption, and viral infections in an arginine-glycine-aspartate independent manner. LM609 entered phase II clinical trials for the treatment of several cancers and was also used for α(V)β(3)-targeted radio...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5689087/ https://ncbi.nlm.nih.gov/pubmed/29033288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.09.007 |
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