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An antibody to the β-secretase cleavage site on amyloid β-protein precursor inhibits amyloid β production
Proteolytic cleavage of amyloid β-protein precursor (AβPP) by β– and γ–secretases results in production of the amyloid β peptide (Aβ) that accumulates in the brains of sufferers of Alzheimer’s Disease (AD). We have developed a monoclonal antibody, 2B12, which binds in the vicinity of the β-secretase...
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| Published in: | J Alzheimers Dis |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492742/ https://ncbi.nlm.nih.gov/pubmed/17183149 |
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