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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Altered amyloid precursor protein (APP) processing leading to increased production and oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP processing is regulated under physiological conditions may provide new insights into AD pathogenesis. Recent reports dem...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hoey, Sarah E., Williams, Robert J., Perkinton, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665739/
https://ncbi.nlm.nih.gov/pubmed/19357271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6017-08.2009
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