AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production

Soluble oligomeric amyloid β peptide (Aβ) generated from processing of the amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's Disease (AD) and through actions at glutamatergic synapses affects excitability and plasticity. The physiological control of APP pro...

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Detalhes bibliográficos
Main Authors: Hoey, Sarah E., Buonocore, Federica, Cox, Carla J., Hammond, Victoria J., Perkinton, Michael S., Williams, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813448/
https://ncbi.nlm.nih.gov/pubmed/24205136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078155
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