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Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Formation of senile plaques containing the β-amyloid peptide (Aβ) derived from the amyloid precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved either by β-secretase or by α-secretase to initiate amyloidogenic (release of Aβ) or nonamyloidogenic processing...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172747/ https://ncbi.nlm.nih.gov/pubmed/12515826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200207113 |
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