NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production

Acute brain injuries have been identified as a risk factor for developing Alzheimer's disease (AD). Because glutamate plays a pivotal role in these pathologies, we studied the influence of glutamate receptor activation on amyloid-β (Aβ) production in primary cultures of cortical neurons. We fou...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Lesné, Sylvain, Ali, Carine, Gabriel, Cecília, Croci, Nicole, MacKenzie, Eric T., Glabe, Charles G., Plotkine, Michel, Marchand-Verrecchia, Catherine, Vivien, Denis, Buisson, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725703/
https://ncbi.nlm.nih.gov/pubmed/16221845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0849-05.2005
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