Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription

Abnormal deposition of Aβ (amyloid-β peptide) is one of the hallmarks of AD (Alzheimer's disease). This peptide results from the processing and cleavage of its precursor protein, APP (amyloid-β precursor protein). We have demonstrated previously that TGF-β (transforming growth factor-β), which...

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Detalhes bibliográficos
Main Authors: Docagne, Fabian, Gabriel, Cecilia, Lebeurrier, Nathalie, Lesné, Sylvain, Hommet, Yannick, Plawinski, Laurent, MacKENZIE, Eric T., Vivien, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134081/
https://ncbi.nlm.nih.gov/pubmed/15242331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040682
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