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BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

Production of amyloid-β protein (Aβ) is initiated by a β-secretase that cleaves the Aβ precursor protein (APP) at the N terminus of Aβ (the β site). A recently identified aspartyl protease, BACE, cleaves the β site and at residue 11 within the Aβ region of APP. Here we show that BACE2, a BACE homolo...

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Bibliografiset tiedot
Päätekijät: Farzan, Michael, Schnitzler, Christine E., Vasilieva, Natalya, Leung, Doris, Choe, Hyeryun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 2000
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC16930/
https://ncbi.nlm.nih.gov/pubmed/10931940
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