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The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology
Amyloid plaques, composed of the amyloid β-protein (Aβ), are hallmark neuropathological lesions in Alzheimer disease (AD) brain. Aβ fulfills a central role in AD pathogenesis, and reduction of Aβ levels should prove beneficial for AD treatment. Aβ generation is initiated by proteolysis of amyloid pr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662048/ https://ncbi.nlm.nih.gov/pubmed/18650431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R800015200 |
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