Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase

Cleavage of amyloid precursor protein (APP) by the Alzheimer's β-secretase (BACE1) is a key step in generating amyloid β-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with β-site APP-cleaving enzyme (BACE) 1 and regulates its cleavag...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Scholefield, Zoe, Yates, Edwin A., Wayne, Gareth, Amour, Augustin, McDowell, William, Turnbull, Jeremy E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2003
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173449/
https://ncbi.nlm.nih.gov/pubmed/14530380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303059
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk