Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase

Cleavage of amyloid precursor protein (APP) by the Alzheimer's β-secretase (BACE1) is a key step in generating amyloid β-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with β-site APP-cleaving enzyme (BACE) 1 and regulates its cleavag...

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Main Authors: Scholefield, Zoe, Yates, Edwin A., Wayne, Gareth, Amour, Augustin, McDowell, William, Turnbull, Jeremy E.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173449/
https://ncbi.nlm.nih.gov/pubmed/14530380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303059
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