Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target, the primary neuronal β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1)....

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Detalhes bibliográficos
Publicado no:Neural Regen Res
Main Authors: Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Procter, Patricia, Miller, Gavin J., Fernig, David G., Guerrini, Marco, Guimond, Scott E., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer - Medknow 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059579/
https://ncbi.nlm.nih.gov/pubmed/31997821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.274341
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