Role of Amyloid-β Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity

The aggregation of the amyloid-β (Aβ) peptide plays a pivotal role in the pathogenesis of Alzheimer's disease, as soluble oligomers are intimately linked to neuronal toxicity and inhibition of hippocampal long-term potentiation (LTP). In the C-terminal region of Aβ there are three consecutive G...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Harmeier, Anja, Wozny, Christian, Rost, Benjamin R., Munter, Lisa-Marie, Hua, Haiqing, Georgiev, Oleg, Beyermann, Michael, Hildebrand, Peter W., Weise, Christoph, Schaffner, Walter, Schmitz, Dietmar, Multhaup, Gerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665404/
https://ncbi.nlm.nih.gov/pubmed/19515926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1336-09.2009
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