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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Guanine-rich DNA can fold into highly stable non-canonical four-stranded DNA structures called G-quadruplexes. These structures present obstacles for the DNA replication machinery, and it has been hypothesized that both eukaryotic DNA helicases and polymerases have evolved to resolve G4 DNA in vivo....
Gardado en:
| Publicado en: | Curr Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6663639/ https://ncbi.nlm.nih.gov/pubmed/29149833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/0929867324666171116123345 |
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