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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Guanine-rich DNA can fold into highly stable non-canonical four-stranded DNA structures called G-quadruplexes. These structures present obstacles for the DNA replication machinery, and it has been hypothesized that both eukaryotic DNA helicases and polymerases have evolved to resolve G4 DNA in vivo....
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| Publicado no: | Curr Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6663639/ https://ncbi.nlm.nih.gov/pubmed/29149833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/0929867324666171116123345 |
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