Mycobacterium tuberculosis DinG Is a Structure-specific Helicase That Unwinds G4 DNA: IMPLICATIONS FOR TARGETING G4 DNA AS A NOVEL THERAPEUTIC APPROACH

The significance of G-quadruplexes and the helicases that resolve G4 structures in prokaryotes is poorly understood. The Mycobacterium tuberculosis genome is GC-rich and contains >10,000 sequences that have the potential to form G4 structures. In Escherichia coli, RecQ helicase unwinds G4 structu...

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Detalhes bibliográficos
Main Authors: Thakur, Roshan Singh, Desingu, Ambika, Basavaraju, Shivakumar, Subramanya, Shreelakshmi, Rao, Desirazu N., Nagaraju, Ganesh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155677/
https://ncbi.nlm.nih.gov/pubmed/25059658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563569
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