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Human Artificial Chromosomes that Bypass Centromeric DNA
Recent breakthroughs with synthetic budding yeast chromosomes expedite the creation of synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend on the histone H3 variant, CENP-A, to epigenetically specify the location of the centromere—the locus essential for chromosome seg...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6657561/ https://ncbi.nlm.nih.gov/pubmed/31348889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.006 |
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