Human Artificial Chromosomes that Bypass Centromeric DNA

Recent breakthroughs with synthetic budding yeast chromosomes expedite the creation of synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend on the histone H3 variant, CENP-A, to epigenetically specify the location of the centromere—the locus essential for chromosome seg...

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Udgivet i:Cell
Main Authors: Logsdon, Glennis A., Gambogi, Craig W., Liskovykh, Mikhail A., Barrey, Evelyne J., Larionov, Vladimir, Miga, Karen H., Heun, Patrick, Black, Ben E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657561/
https://ncbi.nlm.nih.gov/pubmed/31348889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.006
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