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Human artificial chromosome (HAC) for measuring chromosome instability (CIN) and identification of genes required for proper chromosome transmission

Chromosomal instability (CIN) is one of the characteristics of cancer inherent for tumor initiation and progression, which is defined as a persistent, high rate of gain/loss of whole chromosomes. In the vast majority of human tumors the molecular basis of CIN remains unknown. The development of a co...

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Bibliographic Details
Published in:Exp Cell Res
Main Authors: Kouprina, Natalay, Liskovykh, Mikhail, Petrov, Nikolai, Larionov, Vladimir
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029811/
https://ncbi.nlm.nih.gov/pubmed/31877307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2019.111805
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