A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

BACKGROUND: Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a thresh...

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Bibliografiske detaljer
Main Authors: Lee, Hee-Sheung, Lee, Nicholas CO, Grimes, Brenda R, Samoshkin, Alexander, Kononenko, Artem V, Bansal, Ruchi, Masumoto, Hiroshi, Earnshaw, William C, Kouprina, Natalay, Larionov, Vladimir
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Technical Advance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671967/
https://ncbi.nlm.nih.gov/pubmed/23694679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-252
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