Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large distances spanned by these arrays preclude their replication from external sites and imply that the repetitive monomers contain replication origins. However, replication within t...

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Bibliographic Details
Main Authors: Erliandri, Indri, Fu, Haiqing, Nakano, Megumi, Kim, Jung-Hyun, Miga, Karen H., Liskovykh, Mikhail, Earnshaw, William C., Masumoto, Hiroshi, Kouprina, Natalay, Aladjem, Mirit I., Larionov, Vladimir
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191410/
https://ncbi.nlm.nih.gov/pubmed/25228468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku835
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