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Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells
Human artificial chromosome (HAC)-based vectors offer a promising system for delivery and expression of full-length human genes of any size. HACs avoid the limited cloning capacity, lack of copy number control, and insertional mutagenesis caused by integration into host chromosomes that plague viral...
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| Huvudupphovsmän: | , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3250132/ https://ncbi.nlm.nih.gov/pubmed/22123967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114483108 |
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