Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

Human artificial chromosome (HAC)-based vectors offer a promising system for delivery and expression of full-length human genes of any size. HACs avoid the limited cloning capacity, lack of copy number control, and insertional mutagenesis caused by integration into host chromosomes that plague viral...

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Bibliografiska uppgifter
Huvudupphovsmän: Kim, Jung-Hyun, Kononenko, Artem, Erliandri, Indri, Kim, Tae-Aug, Nakano, Megumi, Iida, Yuichi, Barrett, J. Carl, Oshimura, Mitsuo, Masumoto, Hiroshi, Earnshaw, William C., Larionov, Vladimir, Kouprina, Natalay
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250132/
https://ncbi.nlm.nih.gov/pubmed/22123967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114483108
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