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The unique kind of human artificial chromosome: bypassing the requirement for repetitive centromere DNA
Centromeres are essential components of all eukaryotic chromosomes, including artificial/synthetic ones built in the laboratory. In humans, centromeres are typically located on repetitive α-satellite DNA, and these sequences are the “major ingredient” in first-generation human artificial chromosomes...
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| Publicado no: | Exp Cell Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7253334/ https://ncbi.nlm.nih.gov/pubmed/32246994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2020.111978 |
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