Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma

BACKGROUND. Dedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 (MDM2) is used as a diagnostic biomarker; however, no established biomarkers exist to guide DDLPS treatment. In the largest...

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Vydáno v:Oncologist
Hlavní autoři: Bill, Kate Lynn J., Seligson, Nathan D., Hays, John L., Awasthi, Achal, Demoret, Bryce, Stets, Colin W., Duggan, Megan C., Bupathi, Manojkumar, Brock, Guy N., Millis, Sherri Z., Shakya, Reena, Timmers, Cynthia D., Wakely, Paul E., Pollock, Raphael E., Chen, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Sarcomas
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656442/
https://ncbi.nlm.nih.gov/pubmed/31019022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0047
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