Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas

PURPOSE: MDM2 and CDK4 are frequently co-amplified in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS). We aimed to determine whether combined MDM2/CDK4 targeting is associated with higher antitumour activity than a single agent in preclinical models of DDLPS. EXPERIMENTAL DESIGN: DDLP...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Laroche-Clary, Audrey, Chaire, Vanessa, Algeo, Marie-Paule, Derieppe, Marie-Alix, Loarer, François L., Italiano, Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477309/
https://ncbi.nlm.nih.gov/pubmed/28629371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0482-3
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