Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma

BACKGROUND. Dedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 (MDM2) is used as a diagnostic biomarker; however, no established biomarkers exist to guide DDLPS treatment. In the largest...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Bill, Kate Lynn J., Seligson, Nathan D., Hays, John L., Awasthi, Achal, Demoret, Bryce, Stets, Colin W., Duggan, Megan C., Bupathi, Manojkumar, Brock, Guy N., Millis, Sherri Z., Shakya, Reena, Timmers, Cynthia D., Wakely, Paul E., Pollock, Raphael E., Chen, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Sarcomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656442/
https://ncbi.nlm.nih.gov/pubmed/31019022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0047
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