MDM2-Dependent Rewiring of Metabolomic and Lipidomic Profiles in Dedifferentiated Liposarcoma Models

Dedifferentiated liposarcoma (DDLPS) is an aggressive mesenchymal cancer marked by amplification of MDM2, an inhibitor of the tumor suppressor TP53. DDLPS patients with higher MDM2 amplification have lower chemotherapy sensitivity and worse outcome than patients with lower MDM2 amplification. We hyp...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Patt, Andrew, Demoret, Bryce, Stets, Colin, Bill, Kate-Lynn, Smith, Philip, Vijay, Anitha, Patterson, Andrew, Hays, John, Hoang, Mindy, Chen, James L., Mathé, Ewy A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463633/
https://ncbi.nlm.nih.gov/pubmed/32759684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082157
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