Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

Dedifferentiated liposarcoma (DDLPS) is a highly morbid mesenchymal tumor characterized and driven by genomic amplification of the MDM2 gene. Direct inhibition of MDM2 has shown promise pre-clinically, but has yet to be validated in clinical trials. Early in vitro studies have demonstrated that pan-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Seligson, Nathan D., Stets, Colin W., Demoret, Bryce W., Awasthi, Achal, Grosenbacher, Nicholas, Shakya, Reena, Hays, John L., Chen, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779286/
https://ncbi.nlm.nih.gov/pubmed/31620242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27144
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