Phosphorylated Rho-GDP Directly Activates mTORC2 Kinase Toward AKT Through Dimerization with Ras-GTP to Regulate Cell Migration

mTORC2 plays critical roles in metabolism, cell survival, and actin cytoskeletal dynamics via phosphorylation of AKT. Despite its importance to biology and medicine, it is unclear how mTORC2-mediated AKT phosphorylation is controlled. Here, we identify an unforeseen principle by which a GDP-bound fo...

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Publicado en:Nat Cell Biol
Main Authors: Senoo, Hiroshi, Kamimura, Yoichiro, Kimura, Reona, Nakajima, Akihiko, Sawai, Satoshi, Sesaki, Hiromi, Iijima, Miho
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650273/
https://ncbi.nlm.nih.gov/pubmed/31263268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0348-8
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